Head coach Mario Ledesma has made just two changes to the Jaguares starting line-up to face the Lions on Saturday.
Ledesma has brought Bautista Ezcurra in at centre to replace Santiago Iglesias, while Santiago Garcia Botta has come in for Felipe Arregui at prop.
There are two further alterations on the bench with Jeronimo de le Fuente and Ramiro Moyano replacing Juan Martin Hernandez and Sebastian Cancelliere respectively.
The Jaguares have won just one match so far this season – a 38-28 victory over the Waratahs – and succumbed 18-7 to the Reds in their last match.
Jaguares: 15 Joaquin Tuculet, 14 Bautista Delguy, 13 Matias Orlando, 12 Bautista Ezcurra, 11 Emiliano Boffelli, 10 Nicolas Sanchez, 9 Gonzalo Bertranou, 8 Javier Ortega Desio, 7 Marcos Kremer, 6 Pablo Matera (c), 5 Tomas Lavanini, 4 Matias Alemanno, 3 Nahuel Tetaz Chaparro, 2 Agustin Creevy, 1 Santiago Garcia Botta
Replacements: 16 Julian Montoya, 17 Felipe Arregui, 18 Juan Pablo Zeiss, 19 Guido Petti, 20 Juan Manuel Leguizamon, 21 Martin Landajo, 22 Jeronimo de la Fuente, 23 Ramiro Moyano
Date: Saturday, March 24
Venue: Estadio José Amalfitani Vélez Sarsfield, Buenos Aires
Kick-off: 18:40 local (21:40 GMT)
Referee: Jamie Nutbrown (New Zealand)
Assistant referees: Paul Williams (New Zealand), Pablo Deluca (Argentina)
TMO: Santiago Borsani (Argentina)